The science of Health Economics and Outcomes Research is also developing to new dimensions.  Today it is not only a debate about a cost per QALY as a guidance of decision making.  Elements as affordability, Willingness to pay and disease severity are also crucial in understanding and interpreting Health economic research.  New payment models, holistic approaches to budget impact and integration of payment models in real world evidence data collection will be future expertises to help authorities better understand the real impact of the introduction of a new technology on budget, health and productivity.

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